Service 01.

Focused Library

Struggling to find the right library composition? Our Focused Library Service helps you select the most promising compounds based on your target and screening library, turning your High-Throughput-Screening project into a Focused-Screening.

From HTS to Focused Screening

High-Throughput-Screening (HTS) is like looking for a needle in a haystack. Our innovative solution, based on analysing binding sites, decreases the screening space dramatically. Our DiscoveryEngine can shorten the drug discovery process by optimizing the screening process, leading to better results while lowering costs.

Simultaneously, we enrich the diversification of relevant scaffolds and provide an off-target analysis and prediction, which are challenging in the conventional drug discovery process.

Diagram comparing HTS and Focused Screening workflow

Benefits of Using pharmAI Screening Technology

Diverse scaffolds

New and diverse scaffolds enable new opportunities in the search for drug candidates.

Optimized search space

Minimizing and focusing the chemical space reducing experimental costs.

AI-based ranking

Predicted compounds are ranked by using AI and Deep Learning to boost the hit rate.

Service 02.

Scaffold Diversification

Diversify your search space to find analogue compounds with similar binding characteristics in just a few weeks. Extend your search and diversify single to multiple candidates from millions of compounds in your library.

Diversify and Increase Your Hit Rate

pharmAI's Focused Library Service helps our customers to focus their search. After an initial scan of the target or compound, pharmAI's algorithm will predict the chemical subspace where the interaction probability is highest.

  • Multiple focused search spaces where the probability of hits are highest.
  • The proposed spaces are diversified with regard to scaffolds, hence, increasing the diversity of possible hits.
Graphic showing diversification of chemical screening space

Service 03.

Off-Target Identification

Increase your success rate at an early stage. With pharmAI's rapid off-target prediction service you can already find potential off-targets during the discovery stage and get control over potential complications prior to further investments.

Drugs may not always only do what we think they do. Many proposed new drug candidates fail clinical trials due to undesired and potentially harmful side-effects resulting in significant scientific and economic risks.

PharmAI’s DiscoveryEngine searches among hundreds of thousands of proteins and drugs for associations and off-targets using a groundbreaking combination of 3D protein structure data and artificial intelligence.

AI-powered Off-Target Prediction
Accelerated Workflow Diagram

Accelerated workflow

Our optimized workflow predicts potential off-target proteins from the human proteome in less than four weeks. Our screening covers 95% of known human drug targets and de-risks your drug discovery journey at an early stage.

Key Metrics

Our Platform by the Numbers

95%

of the Human Proteome

80B

Compounds

46%

Max Off-Target Hit Rate

32%

Focused Library Hit Rate